منابع مشابه
Loss of Genetic Redundancy in Reductive Genome Evolution
Biological systems evolved to be functionally robust in uncertain environments, but also highly adaptable. Such robustness is partly achieved by genetic redundancy, where the failure of a specific component through mutation or environmental challenge can be compensated by duplicate components capable of performing, to a limited extent, the same function. Highly variable environments require ver...
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The Genetic Programming optimization method (GP) elaborated by John Koza Koza, 1992] is a variant of Genetic Algorithms. The search space of the problem domain consists of computer programs represented as parse trees, and the crossover operator is realized by an exchange of subtrees. Empirical analyses show that large parts of those trees are never used or evaluated which means that these parts...
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Abstract In general redundancy allocation problems the redundancy strategy for each subsystem is predetermined. Tavakkoli- Moghaddam presented a series-parallel redundancy allocation problem with mixing components (RAPMC) in which the redundancy strategy can be chosen for individual subsystems. In this paper, we present a bi-objective redundancy allocation when the redundancy strategies for...
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Genetic and molecular analyses of developmental and physiological processes in numerous experimental systems have recently revealed unsuspected levels of complexity within genetic regulatory pathways. Perhaps most surprising is the result that loss-of-function mutations engineered within many regulatory genes have little or no effect on phenotype. Although the lack of phenotype suggests that th...
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Genetic redundancy is ubiquitous and can be found in any organism. However, it has been argued that genetic redundancy reduces total population fitness, and therefore, redundancy is unlikely to evolve. In this letter, we study an evolutionary model with high-dimensional genotype-phenotype mapping (GPM) to investigate the relevance of complexity in GPM to the evolution of genetic redundancy. By ...
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ژورنال
عنوان ژورنال: Nature
سال: 1997
ISSN: 0028-0836,1476-4687
DOI: 10.1038/40618